Cadherin‐mediated cell‐cell adhesion is perturbed in protein tyrosine kinase (PTK)‐transformed cells. While cadherins themselves appear to be poor PTK substrates, their cytoplasmic binding partners, the Arm catenins, are excellent PTK substrates and therefore good candidates for mediating PTK‐induced changes in cadherin behavior. These proteins, p120ctn, β‐catenin and plakoglobin, bind to the cytoplasmic region of classical cadherins and function to modulate adhesion and/or bridge cadherins to the actin cytoskeleton. In addition, as demonstrated recently for β‐catenin, these proteins also have crucial signaling (...) roles that may or may not be related to their effects on cell‐cell adhesion. Tyrosine phosphorylation of cadherin complexes is well documented and widely believed to modulate cell adhesiveness. The data to date, however, is largely correlative and the mechanism of action remains unresolved. In this review, we discuss the current literature and suggest models whereby tyrosine phosphorylation of Arm catenins contribute to regulation or perturbation of cadherin function. (shrink)

The two vegetative cell types of the acellular slime mould Physarum polycephalum ‐ amoebae and plasmodia ‐ differ greatly in cellular organisation and behaviour as a result of differences in gene expression. The development of uninucleate amoebae into multinucleate, syncytial plasmodia is under the control of the mating‐type locus matA, which is a complex, multi‐functional locus. A key period during plasmodium development is the extended cell cycle, which occurs in the developing uninucleate cell. During this long cell cycle, many of (...) the changes in cellular organisation that accompany development into the multinucleate stage are initiated including, for example, alterations in microtubule organisation. Genes have been identified that show cell‐type specific expression in either amoebae or plasmodia and many of these genes alter their pattern of expression during the extended cell cycle. With the introduction of a DNA transformation system for P. polycephalum, it is now possible to investigate the functions of genes in the vegetative cell types and their roles in the cellular reorganisations accompanying development. (shrink)

Although nurses in almost every long-term care facility face daily challenges involving issues related to residents' sexual lives, guidelines for ethically supporting sexual activity are rare and inadequate. A decision-making framework was developed to guide care providers in responding to the sexual expression of residents in long-term care. The framework recommends that nurses should weigh the documented substantial benefits of having a sexual life against harm to the resident and others, and against offence to others. This article illustrates the use (...) of this ethical decision-making framework by using the example of nurses supporting a resident's expression of his sexuality. It is suggested that nurses use this framework to guide their practice when related ethical issues arise. (shrink)

This essay seeks to understand the complex response to the current Black Lives Matter protests against police violence, which pose deeper questions about the forms of politics that black citizens—who are experiencing a defining moment of racial terror in the United States in the twenty-first century—can and should pursue. When other citizens and state institutions betray a lack of care and concern for black suffering, which in turn makes it impossible for those wrongs to be redressed, is it fair to (...) ask blacks to enact “appropriate” democratic politics? These questions are explored via a reading of Danielle Allen and Ralph Ellison’s meditations on the problem of democratic loss and Hannah Arendt’s critique of school desegregation battles in the 1960s. I suggest that there is a conceptual trap in romantic historical narratives of black activism that recast peaceful acquiescence to loss as a form of democratic exemplarity. (shrink)

Offering intensive care to neonates who have conditions that carry extremely poor prognoses is a source of great contention amongst neonatologists. The concept of best interests is commonly used as a rationale for refusing such care, despite the fact that parents of these infants often have a different view of what best interests means. This article takes up the question of what best interests should incorporate for infants with lethal conditions not curable with intensive care, and how and who should (...) decide which treatment options should be implemented. Based on our recommendation that parents be apprised of the basis upon which physicians are evaluating treatment options, we offer a framework that allows all relevant parties to approach the issue of what is appropriate treatment from a similar place. We maintain that this approach will increase transparency, dialogue, understanding, and trust, which, in turn, may result in greater consensus. (shrink)

Although it is well known that intimacy and sexual expression are an important part of being human and of healthy living, facilities such as nursing homes, adult group homes, or assisted living residences commonly struggle with knowing how to balance supporting residents who are incapable to have sexual lives with their duty to protect them from foreseeable harm. This article presents a challenging case and uses the British Columbia Supporting Sexual Health and Intimacy in Care Facility Guidelines to determine what (...) should be done. (shrink)

As befits an emerging field of enquiry, there is on-going discussion about the scope, role and future of the medical humanities. One relatively recent contribution to this debate proposes a differentiation of the field into two distinct terrains, ‘medical humanities’ and ‘health humanities,’ and calls for a supersession of the former by the latter. In this paper, we revisit the conceptual underpinnings for a distinction between ‘the medical’ and ‘health’ by looking at the history of an analogous debate between ‘medical (...) geography’ and ‘the geographies of health’ that has, over the last few years, witnessed a re-blurring of the distinction. Highlighting the value of this debate within the social sciences for the future development of the medical humanities, we call for scholars to take seriously the challenges of critical and cultural theory, community-based arts and health, and the counter-cultural creative practices and strategies of activist movements in order to meet the new research challenges and fulfill the radical potential of a critical medical humanities. (shrink)

Singular they has emerged as a key term in contemporary gender politics, reflecting growing usage of they/them as nonbinary personal pronouns. Drawing on interviews with 54 progressive gender activists, we consider how singular they can be used to resist and redo aspects of the prevailing gender structure. We identify three distinct usages of singular they: as a nonbinary personal pronoun, as a universal gender-neutral pronoun, and as an indefinite pronoun when a person’s self-identified gender is unknown. While previous research on (...) singular they as a gender-inclusive language practice has focused primarily on its usage as a nonbinary personal pronoun, our findings point to the relevance for gender politics of all three usages. Our analysis offers new insight into how nonbinary they challenges dominant gender norms and practices beyond incorporating additional gender categories. Given our findings, we propose further investigation of how using gender-neutral pronouns for everyone in specific contexts can advance progressive activists’ goals. Finally, we argue that the longstanding usage of singular they as an indefinite pronoun has new importance today in affirming gender as a self-determined identity. (shrink)

We are witnessing a Europe in turmoil, tormented by the violence of ethnic and nationalist struggles which legitimate themselves in the name of identity. This anthology explores the assumptions of identity by disassembling old myths and fictions of unity in relation to the subject, politics and art. Other than identity offers the possibility of rethinking the concept and introducing instead notions of self and other, identity politics and aesthetics. Through theoretical and concrete examples, this study exemplifies the best of current (...) thinking concerning identity. It marks a new venture in multi-disciplinarity, bringing together writers identified with different discursive fields and visual artists to produce work specifically for this publication. Not only will each chapter be a contribution to particular specialist genres but the collection as a whole will offer new possibilities for rethinking identity. The multifarious approach will appeal to a wide spectrum of disciplines and discourses and to anyone with an interest in what is traditionally identified as culture. (shrink)

Although a modus operandi throughout history, the passing down of beliefs and values from parent to child is a practice that must now be challenged. Drawing a connection between fundamentalist religious beliefs and inter-generational violence, this paper examines an ethical dilemma that lies at its crux: on the one hand, the peaceful intentions of fundamentalist believers, and on the other a number of violent consequences for individuals, society, and the world. Applying interdisciplinary religious and peace theory scholarship to the case (...) of Christian fundamentalism in Australia, a number of intertwining issues surrounding religion and education are explored. Should religion be taught to children? What is the difference between indoctrination and education? Is some enculturation desirable? Who decides? Do children have a right to choose their own religion? Do parents have a right to teach them theirs? Is indoctrination avoidable? Is neutrality of the teacher attainable? Does a liberal society have a right not to tolerate the intolerant? How might these complex paradoxes be addressed from a philosophical and peace education perspective? (shrink)

Solidarity-the reciprocal relations of trust and obligation between citizens that are essential for a thriving polity-is a basic goal of all political communities. Yet it is extremely difficult to achieve, especially in multiracial societies. In an era of increasing global migration and democratization, that issue is more pressing than perhaps ever before. In the past few decades, racial diversity and the problems of justice that often accompany it have risen dramatically throughout the world. It features prominently nearly everywhere: from the (...) United States, where it has been a perennial social and political problem, to Europe, which has experienced an unprecedented influx of Muslim and African immigrants, to Latin America, where the rise of vocal black and indigenous movements has brought the question to the fore. Political theorists have long wrestled with the topic of political solidarity, but they have not had much to say about the impact of race on such solidarity, except to claim that what is necessary is to move beyond race. The prevailing approach has been: How can a multicultural and multiracial polity, with all of the different allegiances inherent in it, be transformed into a unified, liberal one? Juliet Hooker flips this question around. In multiracial and multicultural societies, she argues, the practice of political solidarity has been indelibly shaped by the social fact of race. The starting point should thus be the existence of racialized solidarity itself: How can we create political solidarity when racial and cultural diversity are more or less permanent? Unlike the tendency to claim that the best way to deal with the problem of racism is to abandon the concept of race altogether, Hooker stresses the importance of coming to terms with racial injustice, and explores the role that it plays in both the United States and Latin America. Coming to terms with the lasting power of racial identity, she contends, is the starting point for any political project attempting to achieve solidarity. (shrink)

An estimated 14 million children are parented by gay or lesbian couples. Research indicates that children of same-sex parents are as well adjusted as their peers of opposite-sex parents. However, previous research has yet to examine how these youth negotiate their own process of coming out about their families to others. We sought to identify the patterns, issues and themes that recur in the coming out process of these youth. Recommendations for school personnel are described.

Children's exposure to food marketing has exploded in recent years, along with rates of obesity and overweight. Children of color and low-income children are disproportionately at risk for both marketing exposure and becoming overweight.Comprehensive reviews of the literature show that advertising is effective in changing children's food preferences and diets.This paper surveys the scope and scale of current marketing practices, and focuses on the growing use of symbolic appeals that are central in food brands to themes such as finding an (...) identity and feeling powerful and in control.These themes are so potent because they are central to children in their development and constitution of self. The paper concludes that reduction of exposure to marketing will be a central part of any successfu anti-obesity strategy. (shrink)

It is now well recognized that the United States is a consumer-driven society. Private consumption comprises a rising fraction of GDP, advertising is proliferating, and consumerism, as an ideology and set of values, is widespread. Not surprisingly, those developments are not confined to adults; they also characterize what some have called “the commercialization of childhood.” Children are more involved than ever in media, celebrity, shopping, brand names, and other consumer practices. At the core of this change is children's growing role (...) as independent consumers. In recent years, children's access to income has risen markedly, and they have gone from being purchasers of cheap plastic goods and a few select food items to being a major market for a diverse set of goods and services, including foodstuffs. Unofficial estimates suggest that children aged four to twelve spent a reported $6.1 billion in purchases from their own money in 1989, $23.4 billion in 1997, and $30 billion in 2002, for a total increase of four hundred percent. (shrink)

Scenes of violence and incisions into the flesh informeethe demand for law. The scene of little girls being held down in practices of female circumcision has been a defining and definitive image that demands the attention of human rights, and the intervention of law. But the investment in protecting women and little girls from such a cut is not all that it seems.eeLaw's Cuteeon theeeBody of Human Rights: Female Circumcision, TortureeeandeeSacred Flesheeconsiders how such imageseecome to inform laweeand the investment of (...) advocates of law in an imagination of this scene. Drawing on psychoanalytic andeepostcolonialeetheory, and accompanying ideas in political theology, Juliet Rogers examines the language, imagery and excitement that accompanies recenteeinitiatives to legislate against what is called 'female genital mutilation'. The author compliments this examination witheea consideration of the scene of torture exposed in images from Abu Ghraib and Guantanamo Bay.eeRogers argues that the modes ofeefascination and excitement that accompanyeesceneseeof torture and female circumcisioneebetray the fantasy of aeepolitical conditioneeagainst which the subject of liberal law is imagined; this is subjectivityeein aeestate of non-mutilation, non-prohibition or, in a psychoanalytic idiom, non-castration.eeTo support the fantasy of this subject,eethe mutilated subject, the authors suggests, is rendered as flesh cut from the democratic nation state, deserving of only selective human rights, or none at all. (shrink)

Trauma’s ubiquity in society leads to an acknowledgement that damaging experiences likely affect more students than they leave untouched. Dewey acknowledged the importance of the past throughout his theorizing of experience and simultaneously recognized that students need to draw upon past experiences in new learning encounters. In this paper, we argue that Dewey may have opened the door to account for the possibility of traumatic experience affecting learning. We acknowledge the potential of music to prompt a trauma response and seek (...) to explore ways that music education may also provide a mechanism for working through difficult and traumatic pasts. (shrink)

In his political writings, F. A. Hayek faces a classic liberal dilemma: he opposes coercion but recognizes that sometimes the state can help to minimize it. Hayek attempts to resolve the dilemma of the limits of state power by offering a definition of the rule of law that does not depend on a controversial conception of rights. However, his effort to formalize the rule of law fails. Not only does Hayek implicitly rely on an undefended theory of rights, but his (...) rule‐of‐law scheme is limited to the elaboration of general principles of good government, neglecting the need for reforms aimed directly at the political processes that result in the controversial forms of coercion he deplores. (shrink)

In recent years much has been said about how new democracies are backsliding or have regressed since the turn of the century when hope and optimism about the future spread of democracy was widespread. However, ideas that democracy would spread were based on institutional and governance indicators rather than from the perspective of everyday citizens. When we look at public attitudes towards democracy during this period, we can see that such optimism was perhaps misplaced or premature. Drawing on findings from (...) the AsiaBarometer and the World Values Survey, this research finds that public attitudes during this time were not overly convinced by democracy and certainly not yet satisfied with their government's performance in terms of providing basic democratic freedoms and independence. (shrink)

Following a comparative study of canonical liberal philosophers Hayek and Rawls, Juliet Williams reveals a new direction for conceptualizing limited government in the twenty-first century, highlighting the central role that democratic politics--rather than philosophical principles--should play in determining the uses and limits of state power in a liberal regime. Williams draws on recent scholarship in the field of democratic theory and cultural studies in arguing for a shift in the ways liberals approach the study of politics.

eJudicial cooperation is a goal of EU policy. It appears to offer procedural and technical ICT solutions to enhancing EU security. This paper outlines particular dilemmas posed by operationalising ejudicial cooperation within the EU and its member states, and assesses how political weakness is reconfigured as a problem of technical ethics. The application of biometrics and ICT based ejustice potentially bring the EU closer to the citizen without closing the confidence and trust deficit. The paper first outlines three political dilemmas (...) of ejudicial cooperation: political competence, public accountability, and globalisation imperatives. It examines the rationale for introducing biometric IDs, highlighting a general problem of ejudicial cooperation and egovernance which aggravate the trust deficit. Then, it assesses the technical and managerial procedures to ethical practices for quality justice and security to combat the trust deficits which elude open public accountability and compromise trust. (shrink)

In this interview with Isabelle Moeller questions surrounding the responsible use and development of biometric apps are explored. The use of biometrics - originally to digitally represent and authenticate an identifiable characteristic of a product or a person - have become so wide spread that they are capable of facilitating ever greater continuous surveillance of the what, how, when and where of life. The more biometrical data of a user is collected, the more the integrity of the underlying e-identity is (...) open to fraud and being invisibly compromised. Ethical reflection is long overdue but a prerequisite of minimizing risk to the autonomy of the human person as well as to the integrity of his digital persona. (shrink)